| Parameter | Properties |
|---|---|
| Feature | Cold agglutinin disease |
| Definition | Similar to normal erythrocyte except that the region of central pallor is slit like instead of round, reminiscent of a smiling face or fish mouth |
| Conditions associated with the poikilocyte | Congenital stomatocytosis, alcoholic cirrhosis, acute alcohol toxicity |
| Mechanism of formation | Membrane defects, which in some cases lead to increased permeability to sodium and potassium (congenital stomatocytosis) |
| Source/author | William Aird |
| Reviewed and edited by | Parul Bhargava |