Knowledge Check

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What are the 2 major anatomical compartments of the spleen?

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Red pulp
White pulp

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What is the typical upper limit of normal for craniocaudal length of the spleen?

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13 cm

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What is meant by the term “isolated splenomegaly”?

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Splenomegaly that remains undiagnosed despite extensive investigation.

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What are the three mechanistic “buckets” for classification of splenomegaly?

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Work hypertrophy
Infiltration
Congestion

Match the function with the anatomical compartment of the spleen:

Antibody production

Filtration

White pulp

Red pulp

Correct! Sorry, Incorrect.

Sort the causes of splenomegaly according to the mechanism

Cirrhosis

CML

Gaucher

Amyloidosis

Congestive heart failure

Hereditary spherocytosis

Felty’s

Malaria

Cysts

Tubercolosis

Portal vein thrombosis

Infiltration

Work hypertophy

Congestion

True of false: the physical exam is highly sensitive for detecting splenomegaly:

a

True

b

False

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