Knowledge Check

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What are the 2 major anatomical compartments of the spleen?

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Red pulp
White pulp

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What is the typical upper limit of normal for craniocaudal length of the spleen?

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13 cm

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What is meant by the term “isolated splenomegaly”?

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Splenomegaly that remains undiagnosed despite extensive investigation.

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What are the three mechanistic “buckets” for classification of splenomegaly?

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Work hypertrophy
Infiltration
Congestion

Match the function with the anatomical compartment of the spleen:

Antibody production

Filtration

Red pulp

White pulp

Correct! Sorry, Incorrect.

Sort the causes of splenomegaly according to the mechanism

CML

Amyloidosis

Gaucher

Malaria

Hereditary spherocytosis

Cirrhosis

Tubercolosis

Congestive heart failure

Portal vein thrombosis

Cysts

Felty’s

Infiltration

Work hypertophy

Congestion

True of false: the physical exam is highly sensitive for detecting splenomegaly:

a

True

b

False

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