Knowledge Check

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What is ferritin:

a
A protein
b
A carbohydrate
c
A lipd
d
A glycolipid
e
An amino acid

True or false: all ferritin molecules have the same ratio of light and heavy chains:

a
True
b
False

Which of following is/are true about the ferritin heavy chain (more than one answer may apply):

a
It is more abundant than the light chain in serum ferritin
b
It has enzymatic activity that converts Fe2+ to Fe3+
c
Its expression is preferentially induced (vs. light chain) by inflammatory mediators
d
It is the primary component of ferritin in chain found in hyperferritinemia-cataract syndrome

Which is true:

a
Hemosiderin is converted to ferritin
b
Ferritin is converted to hemosiderin

Does hemosiderin have a protein shell?

a
Yes
b
No

Ferritin expression is regulated by iron at the level of:

a
Transcription
b
Translation

Which of following is/are true (more than one answer may apply):

a
Reduced iron increases ferritin levels
b
Inflammaton rarely causes ferritin to increase > 100 ng/ml when iron deficiency is present
c
Iron deficiency causes reduction of ferritin in hyperferritinemia-cataract syndrome
d
Ferritin is an acute phase reactant

Serum ferritin is composed primarily of:

a
Light chain subunits
b
Heavy chain subunits

Serum ferritin is derived primary from:

a
Leakage from damaged cells
b
Classical secretory pathway
c
Nonclassical secretory pathway

True or false: a low serum ferritin (e.g. below 15 ng/ml) is diagnostic of iron deficiency (i.e., high specificity).

a
True
b
False

True or false: a high serum ferritin (e.g. above 500 ng/ml) is usually caused by hemophagocytic lymphohistiocytosis (HLH).

a
True
b
False

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