What are the major mechanistic buckets for splenomegaly?Click for Answer
Sort the causes of splenomegaly into the most appropriate mechanistic bucket:
Portal vein thrombosis
Primary vascular neoplasms
Splenic weight he gold-standard definition of splenomegaly. However, it can only be determined after splenectomy or during post mortem exam, making diagnosis of splenomegaly based on splenic weight impractical. That being said, what spleen weight qualifies as splenomegaly?
For bonus points: what is Traube’s space?Click for Answer
Work hypertrophy may involve one of two histologic areas of the spleen. What are they?Click for Answer
True or false: autoimmune hemolytic anemia and immune thrombocytopenia may be associated with splenomeagly.
Splenomegaly reported in about 20% of patients with chronic autoimmune disorders, secondary at least in part to follicular hyperplasia due to antigenic stimulation.
True or false: sickle cell disease is never associated with splenomegaly, only with asplenia.
Moderate splenomegaly (1-2 cm below the left costal margin) occurs early in life before the spleen atrophies; splenomegaly may also occur in acute splenic sequestration.
Which conditions are associated with massive splenomegaly?
Chronic myelogenous leukemia (CML)
Agnogenic myeloid metaplasia (myelofibrosis)
Hairy cell leukemia
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