Quiz on TTP in Pregnancy • The Blood Project

What is another name for congenital TTP?

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Hereditary TTP

Which of the following statement(s) is/are correct:

a

Hereditary TTP is more common than immune TTP in pregnancy

b

The proportion of cases that are hereditary is higher during pregnancy vs. non-pregnant state

c

TTP in pregnancy is the most common type of TMA in pregnancy

d

Pregnancy is a risk factor for TTP

Why is pregnancy a risk factor for TTP

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Pregnancy normally associated with higher vWF levels and lower ADAMTS13 levels, especially in 3rd trimester

What other TMAs are associated with pregnancy?

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Preeclampsia
HELLP
aHUS

True or false: Urgent delivery is indicated in women with pregnancy-associated TTP.

a

True

b

False

Which of the following are first line therapies for TTP in pregnancy (more than one answer may apply):

a

Therpautic plasma exchange (TPE)

b

Steroids

c

Rituximab

d

Caplacizumab

What is the risk of relapse of hereditary TTP during pregnancy:

a

Around 100%

b

Around 50%

c

0-5%

True or false: Rituximab and caplacizumab are absolutely contraindicated in pregnancy.

a

True

b

False

True or false: The PLASMIC score has been validated in patients with TTP during pregnancy.

a

True

b

False