Quiz on TTP Diagnosis
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True or false: It is safe to wait 3-4 days for the ADAMTS13 level returns before starting treatment for TTP.
a
True
b
False
Which statement(s) is (are) correct?
a
Immune (acquired) TTP is associated with low ADAMTS13 activity level and presence of anti-ADAMTS13 antibodies
b
Immune (acquired) TTP is associated with normal ADAMTS13 activity level and presence of anti-ADAMTS13 antibodies
c
Congenital TTP is associated with low ADAMTS13 activity level and presence of anti-ADAMTS13 antibodies
d
Congenital TTP is associated with low ADAMTS13 activity level and absence of anti-ADAMTS13 antibodies

What are the three principle findings on the peripheral smear of a patient with TTP?
Click for AnswerWhich of the following counts as a point in the PLASMIC score:
a
Elevated MCV
Low MCV, because red cell fragments are smaller than normal RBCs.
b
Elevated creatinine (>2.0 mg/dL)
Normal creatinine! Elevated creatinine points more towards HUS.
c
INR >1.5
Normal INR! Elevated INR points towards DIC.
d
Platelet count < 50 x 10^9/L
Platelet count < 30 x 10^9/L
e
No active cancer in last year
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