Quiz on TTP Definitions

What is the defining feature of TTP?

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Low ADAMTS13 activity level (<10-20%)

How is TMA typically defined (hint: 3 features)

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Thrombocytopenia
Microangiopathic hemolytic anemia (MAHA)
End organ injury

True or false: A normal ADAMTS13 activity level at time of presentation (assuming the blood sample is obtained prior to plasmapheresis) rules out TTP.

a

True

b

False

Which of the following is true:

a

TMA is a type of TTP

b

TTP is a type of TMA

Which of the following is/are characteristic of microangiopathic hemolytic anemia (MAHA)?

a

Hemolytic anemia

b

Schistocytes on blood smear

c

Thrombocytopenia

d

Low haptoglobin

e

Elevated ALT

True or false: the platelet count must be < 30 x 10⁹/L for a patient to qualify as having TTP.

a

True

b

False

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