Knowledge Check

True or false: EDTA is the only cause of spurious/pseudothrombocytopenia.

a
True
b
False
Preanalytic variables such as poor mixing of blood with anticoagulant can also cause platelet aggregation pseudothrombocytopenia.

True or false: EDTA-induced pseudothrombocytopenia is mediated by auto-antibodies.

a
True
b
False

True or false: EDTA-induced autoantibody-mediated pseudothrombocytopenia always involves IgG.

a
True
b
False
IgM and IgA antibodies may also mediate EDTA-induced pseudothrombocytopenia

The prevalence of EDTA-induced pseudothrombocytopenia in outpatients is approximately:

a
0.1%
b
1%
c
2%
d
10%

The prevalence of EDTA-induced pseudothrombocytopenia in inpatients is approximately:

a
0.1%
b
1%
c
2%
d
10%

True of false: platelet aggregation never occurs in citrate anticoagulated blood.

a
True
b
False
Pseudothrombocytopenia RARELY occurs in citrated blood, but through a different mechanism than with EDTA.
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