Knowledge Check

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Pancytopenia is defined as a reduction in:

a
One cell lineage
b
Two cell lineages
c
Three cell lineages
d
Four cell lineages

True or false: peripheral destruction of all three cell lines (red blood cells, white blood cells and platelets) is a common cause of pancytopenia.

a
True
b
False
Autoimmune hemolytic pancytopenia) is very rare.

Medication causes of pancytopenia

  • Most common drugs include:
    • gold salts
    • penicillamine
    • nonsteroidal anti-inflammatory agents such as indomethacin and diclofenac
    • ticlopidine
    • anticonvulsants
Source: Am J Clin Pathol 2013;139:9-29.
Source: Prim Care Clin Office Pract 43 (2016) 559–573.

True or false: pancytopenia is commonly seen in multiple myeloma.

a
True
b
False
Pancytopenia is found in only 10% of patients at presentation.

Which of the following viruses is associated with pancytopenia?

a
HIV
b
EBV
c
Hepatitis C
d
CMV
e
Non A-non B hepatitis

Which of the following are causes of congenital pancytopenia?

a
Fanconi anemia
b
Dyskeratosis congenita
c
Shwachman-Diamond syndrome

Causes of inherited bone marrow failure syndromes

Source: Blood Rev. 2018;32:361-367.
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