Knowledge Check

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What is the definition of pancytopenia?

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Reduction in all three blood cell lines (anemia, thrombocytopenia nd leukopenia)

True or false: many causes of pancytopenia may also be associated with bicytopenia or single cytopenia.

a

True

b

False

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Name the four major mechanistic causes (“buckets”) for pancytopenia

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Underproduction
Infiltration
Destruction
Sequestration

Which of the following conditions is associated with congenital pancytopenia:

a

Bernard Soulier syndrome

b

Shwachman-Diamond syndrome

c

Fanconi anemia

d

Dyskeratosis congenita

e

Gray platelet syndrome

True or false: all patients with pancytopenia should received a bone marrow biopsy.

a

True

b

False

Match the red cell morphology with the condition causing pancytopenia

Ancanthocyte

Teardrop cell

Macrooavalocyte

Myelofibrosis

Cirrhosis (hypersplenism)

Pernicious anemia

Correct! Sorry, Incorrect.

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