The HLH-2004 score was developed primarily for:
True of false: no single clinical or laboratory parameter has sensitivity and specificity to definitively detect HLH.
Hence the use of diagnostic scores like HLH-2004!
Sort the clinical parameter (on top) into HLH-2004 and non-HLH buckets (at bottom):
Mental status changes
Epstein Barr viral load
Low or no NK cell activity
Elevated ferritin level
Elevated sCD25 (sIL-2R)
HLH-2004 diagnostic criteria
Not part of HLH-2004 diagnostic criteria
What is the threshold level for serum ferritin (ng/ml or mg/L) in the HLH-2004 score?
Hyperferritinemia detected in > 90% of adults. values typically range from > 7,000 mcg/L to 10,000 mcg/L; may be > 100,000 mcg/L on occasion. No specific ferritin level determined to be specific for HLH, but negative predictive value of a normal value thought to be high.
What are the thresholds for cytopenias in the HLH-2004 score?Click for Answer
Of the eight HLH-2004 criteria, which is least widely available?Click for Answer
True of false: the HLH-2004 criteria include elevated serum AST and/or ALT levels.
These are included in the HScore.
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