Knowledge Check • The Blood Project

True or false: there is a significant overlap between hemolytic markers and markers of liver disease.

a

True

b

False

Sort the markers of hemolysis according to whether or not they are directly derived from lysed red blood cells:

Haptoglobin

Hemoglobin

AST

Bilirubin

LDH

From RBCs

Not from RBCs

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Liver

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Because it binds plasma hemoglobin (Hb). The Hb-Hp complex is endocytosed by macrophages and the Hp is not recycled.

Recent proteomic approaches have shown that the red blood cell proteome consists of approximately:

a

100 proteins

b

500 proteins

c

1,000 proteins

d

2,000 proteins

e

5,000 proteins

Is it possible that one or more of these 2000 proteins may represent a more specific hemolytic marker?

a

Yes

b

No