Knowledge Check

HbA1c arises from:

a
A posttranslational event
b
A transcriptional event

Which of the following statements is/are correct:

a
Formation of HbA1c is a spontaneous reaction
b
Formation of HbA1c is an irreversible reaction
c
Formation of HbA1c occurs via an enzymatic reaction
d
HbA1c measures glycemic control over the previous 3 month period

HbA1c is formed by attachment of glucose to:

a
Beta chain of hemoglobin
b
Alpha chain of hemoglobin

Which methods can be used to assay HbA1c:

a
HPLC
b
Electrophoresis
Though not typically used now.
c
Immunoassays
d
Boronate affinity chromatography
e
Centrifugation

Sort the conditions according to whether they typically increase or decrease the HbA1c levels:

B12 deficiency
Hyperbilirubinemia
Iron deficiency
Hypertriglyceridemia
Splenomegaly
Asplenia
Acute blood loss
Hemolysis
Uremia
Increased A1C levels
Decreased A1C levels

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