Knowledge Check • The Blood Project

Which of the following parameters is/are included in diagnostic criteria for SLE?

a

Hemolytic anaemia

b

Leukopenia

c

Elevated prothrombin time (PT)

d

Lymphopenia

e

Thrombocytopenia

True of false: neutropenia is the most common hematologic abnormality in SLE.

a

True

b

False

Name two main mechanisms of hematological alterations in SLE

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Autoimmunity
Immunosuppressive treatment

What is the most common white blood cell abnormality in patients with SLE?

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Lymphopenia

Overall, leukopenia occurs in what proportion of patients with SLE:

a

1%

b

10%

Though not typically used now.

c

50%

d

80%

e

Centrifugation

True or false: Leukopenia is common in SLE but rarely needs treatment.

a

True

b

False

True or false: immune-mediated thrombocytopenia in patients with SLE is a type of primary ITP.

a

True

b

False

What is the most cause of anemia in patients with SLE?

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Anemia of inflammation

Most cases of autoimmune hemolytic anemia in patients with SLE present:

a

Prior to diagnosis of SLE

b

At the time of SLE diagnosis

c

Following the diagnosis of SLE

Which statement(s) is/are correct concerning patients with SLE:

a

At higher risk for Hodgkin’s disease than non-Hodgkin’s lymphoma

b

At higher risk for arterial compared to venous thrombosis

c

May develop autosplenectomy and secondary thrombocytosis

d

May develop bone marrow complications including pure red cell aplasia