✅ Hematological abnormalities are commonly seen in patients with anorexia nervosa including:
- Bone marrow changes:
- Gelatinous transformation
✅ Anemia occurs in about 1/3 of patients, is typically normocytic and normochromic and not associated with deficiencies in vitamin B12, folate or iron.
✅ Leukopenia occurs in about 1/3 of patients and is typically characterized by lymphocytopenia and/or neutropenia.
✅ Thrombocytopenia occurs in about 5 to 11% of patients.
✅ Hematological abnormalities:
- May be accentuated during first week of refeeding.
- Ultimately resolve with refeeding after a variable length of time.
✅ Cytopenias in patients with anorexia nervosa believed to be mediated by changes in the bone marrow including marrow hypoplasia, aplasia and gelatinous degeneration of bone marrow.
✅ Because of the reversible nature of hematological changes with refeeding, there is generally no specific treatment required for the cytopenias beyond supportive care with blood transfusion.