Knowledge Check

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Where is EPO produced in the body?

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Primarily in peritubular cells of the kidney, and to a lesser degree in hepatocytes of the liver

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What receptor does EPO bind to?

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Easy one: the EPO receptor, present on the surface of erythroid progenitors!

What are erythropoietin (EPO) levels in people who climb to high altitude?

a

Lower than normal

b

Normal

c

Higher than normal

During ascent to moderate (>5,000 ft) or higher altitudes, endogenous EPO levels rise rapidly peaking in the first 48 hours of altitude exposure.

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Why do patients with renal artery stenosis develop erythrocytosis?

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Local reduction in blood flow (hence oxygen) to oxygen-sensing cells of kidney

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