Corticosteroids in ITP • The Blood Project

250 mg

Which of the following are true about high-dose dexamethasone (HD-DXM) vs. prednisone (PDN) in patients with ITP (more than one answer may apply):

a

HD-DXM results in fewer initial responses (e.g. at 14 days)

b

HD-DXM results in more adverse effects

c

HD-DXM results in more sustained responses (e.g. at 6 months)

d

HD-DXM results in a faster response in platelet count

Which treatment is associated with less bleeding in a patient with ITP?

a

High-dose dexamethasone (HD-DXM)

b

Prednisone (PDN)

Which of the following is/are true:

a

Treatment of ITP with prednisone (PDN) requires a taper

b

PDN taper can be faster in non-responders

c

PDN taper can begin ealier than 4 weeks if the patient achieves early CR

For treating newly diagnosed ITP, clinical practice guidelines recommend (more than one answer may apply):

a

TPO receptor agonists as first line therapy

b

Splenectomy as first line therapy

c

Corticosteroids as first line therapy

d

High-dose dexamethasone (HD-DXM) over prednisone

e

Prednisone over high-dose dexamethasone (HD-DXM)

True or false: if a patient has a poor response to one 4-day cycle high-dose dexamethasone (HD-DXM), they may receive a second cycle.

a

True

b

False