Knowledge Check

Andexanet alfa may be used to reverse which of the following DOACs?

a
Rivaroxaban
Correct. Rivaroxaban is a factor Xa inhibitor.
b
Dabigatran
Dabigatran inhibits thrombin, not factor Xa.
c
Apixaban
Correct. Apixaban is a factor Xa inhibitor.

Andexanet alfa is a modified version of factor Xa that has been mutated at two key sites.