Knowledge Check

True or false: hemoglobin (Hb) E is one of the world’s most common and important mutations.

True

Important because of its association with beta-thalassemia.

False

True or false: hemoglobin (Hb) EE is considered a thalassic phenotype.

True

The mutation activates a cryptic mRNA splice site, which results in reduced synthesis of the β-E chain and leads to a thalassemia phenotype.

False

True or false: HbAE (Hb E trait) and HBEE have no clinical significance.

True

False

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