Knowledge Check

True or false: hemoglobin (Hb) E is one of the world’s most common and important mutations.

a
True
Because of its association with beta-thalassemia.
b
False

True or false: hemoglobin (Hb) EE is considered a thalassic phenotype.

a
True
The mutation activates a cryptic mRNA splice site, which results in reduced synthesis of the β-E chain and leads to a thalassemia phenotype.
b
False

True or false: HbAE (Hb E trait) and HBEE have no clinical significance.

a
True
b
False