Knowledge Check

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True of false: Bleeding is rare in heparin-induced thrombocytopenia (HIT).

a
True
b
False

True of false: Initial presumptive diagnosis of heparin-induced thrombocytopenia (HIT) in the acute setting is made without the benefit of HIT antibody results.

a
True
Initial diagnostic and therapeutic decisions are based on 4T score.
b
False

True of false: A platelet count decrease or a new thrombosis without corresponding HIT antibodies virtually rules out heparin-induced thrombocytopenia (HIT).

a
True
b
False

Which statement(s) is/are true:

a
The 4T score has a high negative predictive value (ie, a low score is useful in ruling out HIT)
b
The 4T score has a high positive predictive value
c
The 4T score has a relatively low positive predictive value

What is more common in patients with heparin-induced thrombocytopenia (HIT):

a
Venous thrombosis
Venous thrombosis occurs twice as frequently as arterial thrombosis.
b
Arterial thrombosis

Is absolute thrombocytopenia required for diagnosis of heparin-induced thrombocytopenia (HIT)?

a
Yes
b
No
No, >30-50% reduction in the platelet count from the highest platelet count after initiation of heparin is required.

True of false: thrombosis in heparin-induced thrombocytopenia (HIT) can occur in any vessel type (vein, artery, capillary).

a
True
b
False

The typical timing of platelet count drop in heparin-induced thrombocytopenia (HIT) is:

a
Within one day of exposure to heparin
b
Between one and five days following exposure to heparin
c
Between five and ten days following exposure to heparin
d
Between ten and twenty days following exposure to heparin

Which of the following is/are true?

a
Immunoassay for HIT antibodies is specific but not sensitive
b
Serotonin release assay is a type of immunoassay
c
Serotonin release assay should be ordered before an immunoassay
d
If the immunoassay is positive, a serotonin release assay is not needed
e
None of the above

True of false: never use a DOAC to treat a patient with heparin-induced thrombocytopenia (HIT).

a
True
b
False
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