Knowledge Check

Which of the following are serum markers of hemolysis?

a
Haptoglobin
b
ALT
c
Urine hemosiderin

No, the question was about serum markers 🙂

d
LDH
e
Direct bilirubin

No, hemolysis is associated with elevated indirect bilirubin.

Which of the following hemolytic markers are derived directly from red cells?

a
Bilirubin
b
Haptoglobin
c
Free hemoglobin
d
LDH
e
AST

True or false: a negative Coombs test (direct antiglobulin test) virtually rules out immune-mediated hemolysis.

a
True
The Combs test may be negative in exceptional cases of immune-mediated hemolytic anemia.
b
False

A negative Coombs test almost always indicates that hemolysis is caused by non-immune mechanisms. These can be divided into extracorpuscular causes and intracorpuscular causes.

What conditions are classically associated with schistocytes on the peripheral smear?

a
Warm autoimmune hemolytic anemia
b
Thrombotic microangiopathy (e.g., TPP)
c
Pyruvate kinase deficiency
d
Microangiopathic hemolytic anemia
e
Spur cell anemia

What are treatment options for a patient with valve hemolysis?

a
Propranol
b
Pentoxifylline
c
Folate
d
Transcatheter repair
e
Open surgical repair