Knowledge Check
- Fever (T > 38.5°C)
- Splenomegaly
- Cytopenias affecting at least 2 cell lineages
- Hgb < 9 g/dL, platelets < 100×109/L, absolute neutrophil count < 100×109/L
- Hypertriglyceridemia (>265 mg/dL) and/or hypofibrinogenemia (<150 mg/dL)
- Hemophagocytosis in bone marrow, spleen, lymph nodes, or liver
- Low or absent NK cell activity
- Ferritin >500 mg/L
- Increased soluble IL2 receptor concentration