Knowledge Check

PKD, PK deficiency; OCD, oxygen dissociation curve

How is PK deficiency diagnosed (2 answers are correct):

a
Very high reticulocyte count
b
PK enzymatic assay
c
Low serum haptoglobin and elevated bilirubin
d
DNA sequencing

True or false: splenectomy is generally contraindicated in patients with PK deficiency?

a
True
b
False