Knowledge Check

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What does PK stand for?

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Pyruvate kinase

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What metabolic pathway does PK participate in?

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Glycolytic pathway (also known as the Embden-Meyerhof pathway)

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What is PK responsible for generating in red cells?

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ATP

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What is the effect of PKD on the OCD?

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Shift to the right; decreased oxygen affinity, increased oxygen offloading in tissues, better tolerance of anemia

PKD, PK deficiency; OCD, oxygen dissociation curve

How is PK deficiency diagnosed (2 answers are correct):

a

Very high reticulocyte count

b

PK enzymatic assay

c

Low serum haptoglobin and elevated bilirubin

d

DNA sequencing

True or false: splenectomy is generally contraindicated in patients with PK deficiency?

a

True

b

False

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