|White cell type
|Appearance of segmented neutrophil with coarse, dense blue-black cytoplasmic granules (varying size and shape, though typically spherical) unevenly distributed in cytoplasm and overlaying/obscuring the nucleus. The granules are larger than those of neutrophils.
|Conditions associated with the cell type
|May be increased in myeloproliferative disorders, hypersensitivity reactions, hypothyroidism, renal disease and iron deficiency.
|Mechanism of formation
|Basophils usually complete their differentiation and maturation in the bone marrow, with mature forms circulating in the bloodstream, constituting less than 1% of circulating leukocytes.
|First identified by Paul Ehrlich in 1879 based on their unique staining properties.
|Semin Immunol 2018;35:29