How is hemoglobinuria detected?

Urine dipstick positive for blood + urine microscopy negative for red cells is consistent with hemoglobinuria or myoglobinuria. Differentiating between hemoglobinuria and myoglobinuria is usually obvious based on the clinical context (for example, serum hemolytic indices positive in hemoglobinuria and serum CK elevated in myoglobinuria), but definitive diagnosis can be made using mass spectrometry.