Neutrophilia: Test Your Understanding

Which of the following is the most common cause of a slightly high neutrophil count?

a
A serious bone marrow disorder
Rare, and usually not a silent finding. Not the usual cause.
b
A recent infection or inflammation
Correct — these are the most common reasons for a mild elevation.
c
A genetic leukocyte disorder
Very uncommon, especially without other symptoms.
d
A vitamin deficiency
Not the usual driver of isolated neutrophilia.

If neutrophilia causes symptoms, what do they usually come from?

a
The high neutrophil count itself
High neutrophils do not cause symptoms on their own.
b
Whatever is triggering the neutrophilia
Yes — symptoms, when they occur, come from the underlying cause (infection, inflammation, stress, etc.).
c
Low iron levels
Iron deficiency does not cause neutrophilia.
d
Too much exercise
Exercise can raise neutrophils temporarily but doesn’t usually cause symptoms.

Which test is most commonly done first when neutrophils are high?

a
A bone marrow biopsy
Very rarely needed and not used as an initial test.
b
Genetic testing (BCR-ABL)
Reserved for very high counts or abnormal smears — not routine.
c
A repeat CBC with differential
Yes — repeating the CBC confirms the finding and looks at all white cell types.
d
A lymph node biopsy
Not appropriate for an isolated mild neutrophil elevation.

Which of the following everyday factors can raise neutrophils without indicating a serious disease?

a
Smoking or nicotine use
Yes — nicotine exposure can raise neutrophil counts, but the health risks of smoking are significant for many other reasons.
b
Low vitamin B12
This does not increase neutrophils.
c
Mild dehydration
This may slightly concentrate the blood but does not cause true neutrophilia.
d
Sun exposure
Not associated with elevated neutrophils.
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