Additional work-up • The Blood Project

What lab tests would you obtain on the patient?

a

Jak2 mutation status

b

Anti-phospholipid antibodies

c

Serum homocysteine level

Guideline recommendations regarding work-up for cause of portal vein thrombosis:

British Journal of Haematology, 2012, 159, 28–38

Guideline recommendations regarding work-up for cause of portal vein thrombosis:

The following lab tests were ordered and were found to be normal:

Antithrombin
Protein C
Protein S
FV Leiden
Prothrombin mutation
Antiphospholipid antibodies
Jak2 V617F

Based on a favorable study comparing warfarin with DOAC in non-cirrhotic PVT, the patient was ultimately switched to Eliquis and was anticoagulated for a total of 6 months. Her portal vein recanalized and she did not have recurrence.